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  • Restraining devices and paralysing drugs can today be so effective that an anaesthetic is often unnecessary from the purely practical point of view. The risk of giving a dose too large and thereby losing an expensive chimpanzee, for example, may often tempt a scientist or technician, inexperienced with sophisticated anaesthetic techniques, to give a dose too small, from which the animal quickly recovers—but not of course until after it has been strapped securely to the operating table.
    • p. 36
  • Differences in reaction to toxic substances vary considerably between species so that the value of these tests remains doubtful. Although thalidomide was extensively tested on animals in several countries, its terrible properties were not discovered. Conversely, penicillin, the greatest medical discovery of the century, was not extensively tested on animals before its miraculous therapeutic qualities were demonstrated in human patients. If it had been fully tested on animals its high toxicity for guinea pigs would have almost certainly prevented its clinical use.
    • p. 37
  • Sometimes captured from the great arboreal freedom of their jungle homes, monkeys are closely confined in cages only three or four feet square. … In order to facilitate cleaning, the animals live upon wire-mesh. They can never sit or lie down on a flat, soft or yielding surface. Little wonder that by the time they are needed for the knife or the needle they are so crazed or inert that they are no longer representative examples of animal life. Psychologists who study the behaviour of thousands of such creatures annually, rarely make allowances for the fact that their pathetic subjects have been so deprived that they have become more like monsters than animals. Many people who have experienced close affectionate relationships with individuals of other species testify to the considerable potential for emotional and intellectual development that animals have. When properly cared for a pet dog or cat can develop great subtleties of behaviour that the laboratory animal never shows. Those who have been fortunate enough to closely observe unfrightened animals living in the wild are often struck by the complexity and richness of the life they lead. These positive pleasures the laboratory animal never knows; for him the same four white walls and the smell of disinfectant.
  • p. 46

Tom Regan, Peter Singer, Animal Rights and Human Obligations, Prentice-Hall, 1976